In the present investigation, a series of novel substituted 6-phenyl-1,8a-dihydro[1,2,4]triazolo[1,5-a]pyridine derivatives (5a-m) have been synthesized via Suzuki-Miyaura coupling reaction. The title compounds were synthesized starting from 5-bromopyridin-2-amine (1). The reaction of compound 1 with hydroxyl amine hydrochloride furnished N-(5-bromopyridin-2-yl)-N'- hydroxylimidoformamide (2), which upon further reaction with acetic anhydride furnished 6-bromo-1,8a-dihydro[1,2,4]triazolo[1,5-a]pyridine (3). The treatment of 6-bromo-1,8a-dihydro[1,2,4]triazolo[1,5-a]pyridine (3) with diverse boronic acids (4a-m) afforded the title compounds (5a-m). The structures of newly synthesized compounds were established by 1HNMR, Mass spectral data and elemental analysis. Further these compounds were screened for antimicrobial activity. The Antimicrobial activity results revealed that compounds 5a, 5e, 5f, 5g, 5l and 5m have shown good activity against all tested organisms at both concentrations whereas compound 5j showed good activity against only fungal species Aspergillus Niger and Trichoderma Virdae.
Loading....